The Virtual Physiological Rat Project is focused on the systems biology of cardiovascular disease—understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Ongoing studies are particularly focused on the inexorable link between cardiac and peripheral physiology/pathophysiology in hypertensive heart disease, aiming to understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Our overall scientific goals are to: (1.) use a systems approach to construct and test new hypotheses on cause-and-effect relationships in the etiology of hypertension and hypertensive heart disease; (2.) discover new strategies for managing, treating, and reversing disease mechanisms and improving/restoring intrinsic cardiac function, neurohumoral control of cardiac function, and physiological blood flow and pressure control; and (3.) use systems modeling to improve diagnosis and realize applications in precision medicine for cardiovascular disease.
Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study
J. Phys. Chem. B, Article ASAP, 2016.
Biomed Res Int. 2015:370194, 2015. PMID: 26229957 PMCID: PMC4503556
Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle.
J Molecular and Cellular Cardiology 96:11-25, 2015.
Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake
J Physiol. 2014 May; 592(Pt9): 1917-30. PMCID: PMC4230769
March 1, 2016
January 11, 2016
July 7, 2015
June 2, 2015
February 18, 2015