Our laboratory uses a combination of experimental and systems modeling approaches to understanding the operation of physiological systems in health and disease. Current projects use multi-scale models to simulate the integrated operation of metabolic pathways (e.g., oxidative ATP synthesis in the heart), cellular functions (e.g., cellular calcium handling and actin/myosin cross-bridge dynamics), whole-organ function (e.g., mechanics of cardiac pumping), and whole-body body cardiopulmonary function. Dr. Beard currently supervises trainees from several different degree-granting programs in the university, and organizes and teaches in courses in physiology, bioinformatics, and computational biology.