Edith Jones was awarded a Ruth L. Kirschstein predoctoral National Research Service Award. The award, titled “Causes and consequences of myocardial purine dysregulation in heart failure” will help fund Ms. Jones’ dissertation research on purine degradation in heart failure in humans. These studies will test the hypotheses that in heart failure the human heart is disposed to a pathological depletion of adenine nucleotides and that this depletion impedes myocardial crossbridge cycle kinetics, impairing cardiac pumping in heart failure. To test these hypotheses, we are obtaining data across multiple biological scales from patient records, from non-invasive phenotyping of human subjects, and biochemical assessment of tissue from explanted hearts. As crucial means of hypothesis testing and refinement, we are using multi-scale computational models of mechanical-metabolic coupling to simulate and probe integrated systems behavior in heart failure, a multi-factorial disease affecting and affected by every major organ system in the body.